Here is the route of the Trans-Canada Highway (#1) from east to west:
The route through eastern Saskatchewan passes through some of the flattest land you'll ever see, scoured flat by the glaciers of the last ice age (expecialy around the towns of Weyburn, Estevan). For variety, take the time to explore the roads south or north of the highway. Moose Mountain Provincial Park, a recreatonal oasis 80 km south of the highway from Whitewood. You can also take Route 9 (or 201 if you missed it) north from Whitewood past Crooked Lake, Katepwa, and Echo Valley provincial parks in the beautiful Qu'Appelle valley.
Regina is a surprisingly modern-looking prairie city of 200,000 people. It was built around the artificial Wascana Lake, with many government and recreational buildings close to the water. The route west from Regina takes you past Moose Jaw, which during the 1920s prohibition era gained the reputation of "Chicago North" because of its underground tunnels to help smugglers evade police capture.
Saskatchewan Road Map Itineraries along the Trans-Canada:
West of Moose Jaw, you drive through 175 km of grassland prairie before passing Swift Current and Maple Creek. To the north of the highway, is Saskatoon Landing Provincial Park is on the river, north of town via Route 4.
Cypress Hills Interprovincial Park, with the tallest hills between Labrador and the Rockies, is south of the Trans-Canada Highway via Route 21.
Here is the northern route of the Trans-Canada, the Yellowhead Highway (#16) from east to west:
You'll drive through the city of Yorkton in the east, and pass by Good Spirit Lake Provincial Park, just north of Yorkton (via Route 47). After
another 330 kilometres, you arrive at Saskatoon, Saskatchewan's biggest city
(its a bit bigger than Regina) and is very pretty with it riverside location, and has lots of restaurants and nightlife given the sizeable university population. West
of Saskatoon the highway leads you across the South Saskatchewan and then
the North Saskatchewan rivers to North Battleford, and the nearby Battlefords Provincial Park, 20 miles to the north (via Route 4). The highway exits the province at the city of Lloydminster, which is the centre for heavy oil production in the area, and literally straddles the provincial border.